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However, high-dose supplementation, particularly for non-health reasons like skin lightening, is generally not recommended due to a lack of clinical research

Moreover, a cohort of 2500 patients has been reported to contain de novo missense and nonsense mutation of histodemethylase KDM5B

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[DOI] [PubMed] [Google Scholar] Carver-Moore K, Broxmeyer HE, Luoh SM, Cooper S, Peng J, Burstein SA, Moore MW and de Sauvage FJ

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